3RD LATIN-AMERICAN WORKSHOP ON NEUROBIOLOGY OF EPILEPSY
3RD LATINAMERICAN WORKSHOP ON NEUROBIOLOGY OF EPILEPSY
REDISIGNING THE HYPOTHESES FOR DRUGRESISTANT EPILEPSY
Drug-resistant epilepsy affects approximately one-third of the patients with epilepsy. Several experimental models have been used to understand the mechanisms involved in pharmacoresistant epilepsy and to identify novel therapies to control this condition. Moreover, the mechanisms of drug resistance in epilepsy are explained by specific hypotheses, which are not mutually exclusive. However, the global prevalence of this disease persists without changes. In the present workshop, different conditions that could explain this situation will be presented. We will discuss the limitations of the different hypothesis used to explain the pharmacoresistance in epilepsy. For example, these hypotheses as well as the different experimental models designed for the screening of antiseizure drugs do not consider factors such as age, gender, type of epilepsy and comorbid disorders. The final discussion will be focused to establish a global hypothesis that integrates the central and peripheral phenomena associated with pharmacoresistant epilepsy.
DRUG RESISTANCE HYPOTHESIS I
Introduction to the III Latin-American Workshop on Neurobiology of Epilepsy
Hypothesis of the intrinsic severity What about the high frequency oscillations?
Hypothesis of the therapeutic target going beyond the receptors
Hypothesis of the gene variant with or without epigenetics
Hypothesis of pharmacokinetics the role of the blood-brain barrier
DRUG RESISTANCE HYPOTHESIS II
Hypothesis of the neural network a multimodal condition
Hypothesis of transporter central or peripheral?
Neuroinflammation an alternative hypothesis for drug-resistant epilepsy?
INTEGRAL DRUG RESISTANCE HYPOTHESIS
Factors not considered in the study of drug-resistant epilepsy I : Age and gender
Factors not considered in the study of drug-resistant epilepsy II : Comorbid psychiatric disorders
Unconventional targets for the control of drug-resistant seizures
Brain stimulation as strategy for assessing drug resistant epilepsy
Discussion session In search of a comprehensive hypothesis that explains the drug-resistant epilepsy