PROGRAMME

The International Scientific and Organising Committee is working to create a programme that represents the best European and global epileptology.

The programme will cover all aspects of epileptology, but four main themes have been selected, representing Adult Epileptology, Basic Science, Paediatric Epileptology and Pharmacology.

Sessions will include the Chairs’ Symposium, Special Symposia, Teaching Courses and Sessions, Platform Sessions, ECE Forums, the Symposium of Excellence in Epileptology, among others.

Click on the image below to view the overview of the programme schedule.

Please check back here for updates as the ISOC develops the programme.

Chairs’ Symposium: Precision medicine for patients with epilepsy – are we there yet?

Co-chairs: Eugen Trinka (Austria) & Margitta Seeck (Switzerland)

  • How genetic findings impact patients’ treatment and prognosis
  • New imaging tools will advance patients’ diagnosis and treatment to the next level
  • New avenues in drug development will have an impact on patients’ life
  • What is needed to bring advances in diagnosis and treatment to the population? – The global implementation gap

 

Neurodegeneration and epilepsy

  • Neurodegenerative disorders and seizures – the epidemiological view
  • The ABT of neurodegeneration: alpha synuclein, beta amyloid, and tau protein and their role in epileptogenesis
  • Diagnosis – neuroimaging, CSF, EEG
  • Therapeutic challenges of treating patients with epilepsy and neurodegenerative disorders
  • Antiseizure drugs in Alzheimer’s disease: are they potent disease modifiers?

 

Novel approaches to drug discovery

  • Why we need novel approaches
  • Novel models of paediatric epilepsies
  • Zebra fish as tools for personalised medicine
  • Use of gene networks and induced pluripotent stem cells in drug discovery

 

Is it possible to predict outcome in childhood epilepsies?

  • The role of genetics: where to start for understanding outcome
  • Disease modifying treatments: is there an option?
  • Prediction of outcome after epilepsy surgery: what can we learn from the virtual brain?
  • How EEG, MRI and neuroimaging of brain networks can help?
  • The sooner, the better

 

Future therapies for epilepsy

  • Update on new antiepileptic drugs in the pipeline
  • Can we develop new therapies for therapy-resistant patients?
  • Impact of new regulatory guidelines on drug development approaches
  • Innovative treatments for orphan epilepsies, one at a time?
  • Update on new antiepileptic devices in the pipeline

 

WHO Session

Programme tbc

Epilepsy and inflammation – hen or egg, or neither of them?

  • When inflammation causes epilepsy: the case for autoimmune encephalitis “hen, egg or neither of them part I”?
  • When epilepsy causes inflammation: “hen, egg or neither of them part II”?
  • Rare or new causes of autoimmune encephalitis: “from hens and eggs…”
  • Immune histopathology of autoimmune encephalitis: “scrambled eggs on the microscope…”

 

ILAE-YES Session: The future of epileptology in 20 years: science or fiction?

  • Computational modelling of epilepsy and predicting neurosurgical outcomes
  • Gauging seizure risk and tailoring epilepsy treatment using multiday cycles
  • From genes to therapy – how genetic mutations can determine our treatment
  • Detecting seizures and preventing SUDEP

 

Future diagnostics in epilepsy – are automated methods going to replace clinicians?

  • Artificial intelligence in digital pathology – long way to real intelligence
  • Automated detection of focal cortical dysplasia using deep learning
  • Automated EEG processing in epilepsy
  • Computer-assisted planning of SEEG and laser trajectories: man vs. machine

 

The GABA wave 35 years on: the lessons from GABAergic drugs for future drug development

  • The GABA wave – a history of vigabatrin and CNS-active GABA derivatives in epilepsy
  • How vigabatrin, progabide and tiagabine affected the development of new CNS-active GABA derivatives
  • The current role of GABA derivatives in epilepsy treatment
  • Can we develop better GABA Derivatives than the currently available commercially?

 

Genetic therapy for refractory epilepsy

  • Seizure suppression with neuropeptide gene therapy
  • CRISPR gene therapy for epilepsy
  • Auto-regulatory gene therapy for epilepsy
  • RNA therapy for epilepsy

 

Electromagnetic source imaging in presurgical evaluation: get it into your clinical practice!

  • EEG source imaging of interictal epileptiform discharges
  • EEG source imaging of ictal activity
  • MEG source imaging
  • EEG connectivity in presurgical evaluation

 

Multi-scale recordings: new windows on epileptic networks

  • Simultaneous EEG-SEEG during electrical cortical stimulation
  • Can we detect mesial activity non-invasively? Insights from simultaneous MEG/EEG/SEEG recordings
  • Microelectrode recordings reveal the organisation of ictal neuronal behaviour
  • A multiscale analysis of fast-ripples in epileptic patients: their relations to single neuron activity and interictal epileptic discharges

 

Predict and monitor epilepsy after the first epileptic seizure: new tools from EEG and imaging

  • Prediction of outcome based on clinical variables
  • First seizure and new-onset epilepsy: the Geneva experience
  • Diagnostic yield of advanced MRI imaging in a first seizure setting
  • The present and future: are there EEG biomarkers for seizure recurrence?

 

Biology and treatments for CDKL5 Deficiency Disorder

  • Biology of CDKL5 deficiency
  • Preclinical treatments in development for CDD
  • Clinical presentation of CDD
  • Clinical treatments in development for CDD

 

Safety first – how to use registries for improved patient care

  • Population-based studies for diagnosis and predictions of risks
  • The use of therapeutic drug monitoring and prescription databases to monitor safety at the patient and population levels
  • The use of a prescription registry for surveillance of adherence and success of treatment
  • Mortality and life expectancy in epilepsy

 

The potential of transcranial magnetic stimulation in epilepsy care

  • State of the art of TMS in epilepsy – presentation of the EpiStim Consortium
  • TMS-EEG to track response to pharmacological treatment in epilepsy
  • TMS-EEG as a tool in genotype-phenotype correlation
  • TMS-EEG in the epilepsy monitoring unit

 

The role of (epi)genetics in epilepsy: new targeting strategies and implications for diagnosis and treatment

  • Critical role of DNA methylation and histone modification changes for the development and progression of epilepsy
  • (Post)transcriptional profiling in human epilepsy
  • Small non-coding RNAs as novel therapeutic targets and biomarkers for epilepsy
  • Circadian regulation of gene expression following acquired epileptic insults and seizures

 

Sodium channel epileptic encephalopathies: phenotypic heterogeneity and therapeutic options

  • SCN1A related phenotypes, novel neurobiological concepts and therapies
  • Genetic and phenotypic heterogeneity and therapeutic implications in SCN2A-related disorders
  • The phenotypic spectrum of SCN8A-related disorders and treatment options
  • Voltage-gated Na+ channels: electrophysiology, pathophysiology and therapeutic implications

 

Super-refractory Status Epilepticus – the way forward

  • How good are the conventional therapies?
  • Tearing up the pharmacokinetic principles of epilepsy
  • Novel approaches
  • Why try immunological therapy?

 

Women and epilepsy – lifelong considerations

  • Epilepsy, hormones and the menstrual cycle
  • Epilepsy and new mothers
  • Epilepsy and older women
  • Quality of life in women with epilepsy

 

Individualising antiepileptic drug treatment

  • Therapeutic drug monitoring
  • Treatment response prediction
  • Inflammatory biomarkers for epilepsy
  • Prediction of drug side-effects

 

Antiepileptogenesis, the holy grail: how can we find and assess potential treatments?

  • Genomic approaches to drug repurposing
  • Antiepileptogenesis in high risk patients following acute brain insults
  • Antiepileptogenesis in high risk patients following first seizure

 

Clinical neurophysiology for coma prognostication after cardiac arrest

  • Introduction from a neurointensive standpoint
  • EEG: prognostic value and status epilepticus detection
  • SSEP: pearls and pitfalls
  • Postanoxic SE management

 

Seizure dynamics on the scale of years, days, hours and seconds

  • Seizure dynamics on the scale of years
  • Seizure dynamics on the scale of days
  • Seizure dynamics on the scale of hours
  • Seizure dynamics on the scale of seconds

 

Mapping brain function

  • An electrical atlas of the brain
  • A road map of the brain
  • A cognitive map of the brain
  • How reliable is brain stimulation for brain mapping?

 

Pharmaco MRI in epilepsy

  • Antiepileptic drugs effects on cognitive networks as revealed by functional MRI
  • Antiepileptic drugs effects on epilepsy networks
  • Antiepileptic drugs and structural cortical/subcortical brain changes

 

What should child neurologists know when treating children with comorbidities?

  • Therapeutic approaches to children with mood and anxiety disorders – Isobel Heyman (United Kingdom)
  • Managing behavioural disorders in children with epilepsy and autism at the transition phase – Martha Feucht (Austria)
  • AED choice for children with a neuropsychiatric comorbidity – Kette Valente (Brazil)
  • The impact of epilepsy surgery in the presence of neuropsychiatric disorders – Elaine Wirrell (USA)

 

Dravet Syndrome beyond epilepsy

  • SUDEP and acute encephalopathy in Dravet Syndrome
  • Language – communication disorder
  • Behavioural aspects / issues
  • Orthopaedic and gait problems
  • Sleep disorder

 

Neuropsychiatric challenges in epilepsy care

  • Treatment of psychiatric comorbidities in patients with epilepsy and intellectual disabilities: is there a role for the neurologist?
  • Pharmacotherapy in patients with epilepsy and psychosis
  • The association of panic and hyperventilation with psychogenic non-epileptic seizures in patients with PNES
  • Delineating behavioural and cognitive phenotypes in juvenile myoclonic epilepsy: are we missing the forest for the trees?

 

Diagnosing neuropsychiatric conditions in paediatric epilepsy

  • Depression and anxiety in children with epilepsy: key steps to the diagnosis
  • A neuropaediatric approach to autism
  • The identification of ADHD in childhood and adolescence
  • The role of transition clinics in the identification and prevention of psychiatric comorbidities

 

Optimising resection planning and clinical outcomes following epilepsy surgery

  • The importance of identifying white matter tracts in optimising resections in epilepsy surgery
  • Imaging and navigating white matter tracts to optimise patient outcome
  • What neurophysiology of the white matter tracts can teach us about epilepsy and neurological function
  • Techniques to improve extent of surgical resection and minimise morbidity

 

Non- and minimal-invasive ablation: the future, the past and the present

  • The future: MR-guided-focused ultrasound: why are certain epileptogenic lesions are putative targets?
  • Thermocoagulation
  • The present I: MR-guided-laser-interstitial thermal therapy: in 10 years from single cases to larger series
  • The present II: cases in Europe – how the overseas experiences influenced our perception

 

Advances in understanding of focal cortical dysplasias and the mTOR pathway

  • The neurobiology of mTOR pathway
  • Neuropathological spectrum of cortical malformations as basis for improved pathogenetic understanding
  • Brain somatic mTOR mutations in focal cortical dysplasias: relevance for clinical diagnosis
  • Electro-clinico-imaging phenotype of genetic focal cortical dysplasias

 

Update in hemispherotomy: chances, challenges and perspectives

  • Challenges and updates in hemispheric surgery
  • Predicting long-term seizure outcomes
  • Predicting long-term functional outcomes
  • Predicting long-term cognitive  outcomes

ILAE-Europe – EAN Symposium

Programme tbc

 

Stroke and epilepsy:  unresolved issues of key noncommunicable diseases

  • Prevention of seizures in acute stroke: are we there yet?
  • Reperfusion therapies and seizure development – is there an association?
  • Young and elderly stroke patients with epilepsy
  • Seizures imitating strokes imitating seizures

Full-day Teaching Course:

Neuroimaging in epilepsy – what the clinician should know

 

Half-day Teaching Courses:

Is this a seizure? If not, what is it?

Classify this!

Let´s read EEGs together!

Which AED to start with? When to stop?

No response to AED. What next?

Genetic testing: whom, when and what to test

Epilepsy surgery: learn from cases!

Status epilepticus

 

Teaching Courses/Sessions:

VIREPA Basic & Advanced EEG

VIREPA Paediatric EEG & Sleep

Advanced EEG: source imaging – part 1 (Theory)

Advanced EEG: source imaging – part 2 (Hands-on)

Video session – paediatric

Video session – adult

Immunity, inflammation and epilepsy

Epileptic encephalopathies